Pediatric postoperative cerebellar cognitive affective syndrome follows outflow pathway lesions.

ABSTRACT:

Objective

To evaluate lesion location after pediatric cerebellar tumor resection in relation to the development of severe cognitive and affective disturbances, or cerebellar cognitive affective syndrome (CCAS).

Methods

The postsurgical lesion location of 195 pediatric patients with cerebellar tumors was mapped onto a template brain. Individuals with CCAS were matched to 2 participants without CCAS by sex, age, and lesion volume. Lesion analyses included both a hypothesis-driven evaluation of the cerebellar outflow pathway (deep nuclei and superior cerebellar peduncles) and data-driven multivariate lesion symptom mapping. Lesion-associated networks were evaluated by comparing connectivity patterns between the lesion location of cases with and those without CCAS with resting-s

SUBMITTER: Albazron FM 

PROVIDER: S-EPMC6815203 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature