Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.

ABSTRACT:

Background

The serum level of osteoprotegerin (encoded by OPG or TNFRSF11B) was previously shown to be increased in patients with ischemic stroke. A single nucleotide polymorphism rs3134069 in the TNFRSF11B gene was previously associated with ischemic stroke in a population of diabetic patients in Italy. It remains to be determined whether rs3134069 is associated with ischemic stroke in the general population or populations without diabetes.

Materials and methods

We genotyped rs3134069 and performed a case-control association study to test whether rs3134069 is associated with ischemic stroke in 2 independent Chinese Han populations, including a China-Central population with 1629 cases and 1504 controls and a China-Northern population with 1206 cases and 720 controls.

Resu

SUBMITTER: Xiong X 

PROVIDER: S-EPMC6815228 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature