Mucoid Pseudomonas aeruginosa and regional inflammation in the cystic fibrosis lung.

ABSTRACT:

Background

Pseudomonas aeruginosa is the prominent bacterial pathogen in the cystic fibrosis (CF) lung and contributes to significant morbidity and mortality. Though P. aeruginosa strains initially colonizing the CF lung have a nonmucoid colony morphology, they often mutate into mucoid variants that are associated with clinical deterioration. Both nonmucoid and mucoid P. aeruginosa variants are often co-isolated on microbiological cultures of sputum collected from CF patients. With regional variation in bronchiectasis, tissue damage, inflammation, and microbial colonization, lobar distribution of nonmucoid and mucoid P. aeruginosa variants may impact local microenvironments in the CF lung, but this has not been well-studied.

Methods

We prospectively collected lobe-specific b

SUBMITTER: Malhotra S 

PROVIDER: S-EPMC6815243 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature