Immunolocalization of calcium sensing and transport proteins in the murine endolymphatic sac indicates calciostatic functions within the inner ear.

ABSTRACT: An exceptionally low calcium (Ca²⁺) concentration in the inner ear endolymph ([Ca²⁺]_endolymph) is crucial for proper auditory and vestibular function. The endolymphatic sac (ES) is believed to critically contribute to the maintenance of this low [Ca²⁺]_endolymph. Here, we investigated the immunohistochemical localization of proteins that are presumably involved in the sensing and transport of extracellular Ca²⁺ in the murine ES epithelium. Light microscopic and fluorescence immunolabeling in paraffin-embedded murine ES tissue sections (male C57BL/6 mice, 6-8 weeks old) demonstrated the presence of the calcium-sensing receptor CaSR, transient receptor potential cation channel subtypes TRPV5 and TRPV6, sarco/endoplasmic reticul

SUBMITTER: Bachinger D 

PROVIDER: S-EPMC6815286 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature