Interpreting HIV diagnostic histories into infection time estimates: analytical framework and online tool.

ABSTRACT:

Background

It is frequently of epidemiological and/or clinical interest to estimate the date of HIV infection or time-since-infection of individuals. Yet, for over 15 years, the only widely-referenced infection dating algorithm that utilises diagnostic testing data to estimate time-since-infection has been the 'Fiebig staging' system. This defines a number of stages of early HIV infection through various standard combinations of contemporaneous discordant diagnostic results using tests of different sensitivity. To develop a new, more nuanced infection dating algorithm, we generalised the Fiebig approach to accommodate positive and negative diagnostic results generated on the same or different dates, and arbitrary current or future tests - as long as the test sensitivity is known. F

SUBMITTER: Grebe E 

PROVIDER: S-EPMC6815418 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature