Dynein activating adaptor BICD2 controls radial migration of upper-layer cortical neurons in vivo.

ABSTRACT: For the proper organization of the six-layered mammalian neocortex it is required that neurons migrate radially from their place of birth towards their designated destination. The molecular machinery underlying this neuronal migration is still poorly understood. The dynein-adaptor protein BICD2 is associated with a spectrum of human neurological diseases, including malformations of cortical development. Previous studies have shown that knockdown of BICD2 interferes with interkinetic nuclear migration in radial glial progenitor cells, and that Bicd2-deficient mice display an altered laminar organization of the cerebellum and the neocortex. However, the precise in vivo role of BICD2 in neocortical development remains unclear. By comparing cell-type specific conditional Bicd2 knock-out mice,

SUBMITTER: Will L 

PROVIDER: S-EPMC6815425 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature