Case report: whole genome sequencing based investigation of maternal-neonatal listeriosis in Sichuan, China.

ABSTRACT:

Background

Neonatal listeriosis is a rare but severe disease manifesting as septicemia and central nervous system (CNS) infections with a high fatality rate of around 20 to 30%. Whole genome sequencing (WGS) is a promising technique for pathogen identification and infection source tracing with its high resolution.

Case presentation

A case of neonatal sepsis with listeriosis was reported with positive blood culture for Listeria monocytogenes. The case was investigated to confirm the vertical transmission of the infection and identify the potential food source of the maternal L. monocytogenes infection using WGS. L. monocytogenes was isolated from the neonate's blood sample the day after caesarean delivery and from the mother's genital and pudenda swab samples 5 days and 13 da

SUBMITTER: Luo L 

PROVIDER: S-EPMC6815428 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature