Cytotoxic Phenolic Compounds from Fruit Glandular Trichomes of Macaranga tanarius.

ABSTRACT: A new flavonoid, macatanarin D (1), together with five known stilbenes (2-6), was isolated from fruit glandular trichomes of Macaranga tanarius. Their structures were elucidated on the basis of spectroscopic methods and through comparison with data reported in the literature. All isolated compounds were evaluated for their cytotoxic activities against KB and MCF-7 cell lines. Compounds 3, 4, and 5 showed the strongest activities against both cell lines with IC₅₀ values in the range of 0.03-0.12 μM, and compound 2 only showed a significant cytotoxicity against KB cell line (IC₅₀ = 0.26 μM) and a moderate cytotoxicity against MCF-7 (IC₅₀ = 10.4 μM). Compounds 1 and 6 showed we

SUBMITTER: Doan TMH 

PROVIDER: S-EPMC6815561 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature