Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.

ABSTRACT: Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the

SUBMITTER: Rivas-Santiago C 

PROVIDER: S-EPMC6815581 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature