A Functional Interaction Between Na,K-ATPase β₂-Subunit/AMOG and NF2/Merlin Regulates Growth Factor Signaling in Cerebellar Granule Cells.

ABSTRACT: The Na,K-ATPase, consisting of a catalytic α-subunit and a regulatory β-subunit, is a ubiquitously expressed ion pump that carries out the transport of Na⁺ and K⁺ across the plasma membranes of most animal cells. In addition to its pump function, Na,K-ATPase serves as a signaling scaffold and a cell adhesion molecule. Of the three β-subunit isoforms, β₁ is found in almost all tissues, while β₂ expression is mostly restricted to brain and muscle. In cerebellar granule cells, the β₂-subunit, also known as adhesion molecule on glia (AMOG), has been linked to neuron-astrocyte adhesion and granule cell migration, suggesting its role in cerebellar development. Nevertheless, little is known about molecular pathways that link the β₂

SUBMITTER: Litan A 

PROVIDER: S-EPMC6815692 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature