Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.

ABSTRACT:

Rationale

Inducing cancer differentiation is a promising approach to treat cancer. Here, we identified chlorogenic acid (CA), a potential differentiation inducer, for cancer therapy, and elucidated the molecular mechanisms underlying its differentiation-inducing effects on cancer cells.

Methods

Cancer cell differentiation was investigated by measuring malignant behavior, including growth rate, invasion/migration, morphological change, maturation, and ATP production. Gene expression was analyzed by microarray analysis, qRT-PCR, and protein measurement, and molecular biology techniques were employed for mechanistic studies. LC/MS analysis was the method of choice for chemical detection. Finally, the anticancer effect of CA was evaluated both in vitro and in vivo.

SUBMITTER: Huang S 

PROVIDER: S-EPMC6815948 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature