Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular zinc levels.

ABSTRACT: Zinc transporter 1 (ZNT1) is the only zinc transporter predominantly located on the plasma membrane, where it plays a pivotal role exporting cytosolic zinc to the extracellular space. Numerous studies have focused on the physiological and pathological functions of ZNT1. However, its biochemical features remain poorly understood. Here, we investigated the regulation of ZNT1 expression in human and vertebrate cells, and found that ZNT1 expression is posttranslationally regulated by cellular zinc status. We observed that under zinc-sufficient conditions, ZNT1 accumulates on the plasma membrane, consistent with its zinc efflux function. In contrast, under zinc-deficient conditions, ZNT1 molecules on the plasma membrane were endocytosed and degraded through both the proteasomal and lysosomal pa

SUBMITTER: Nishito Y 

PROVIDER: S-EPMC6816103 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature