Domainoid: domain-oriented orthology inference.

ABSTRACT:

Background

Orthology inference is normally based on full-length protein sequences. However, most proteins contain independently folding and recurring regions, domains. The domain architecture of a protein is vital for its function, and recombination events mean individual domains can have different evolutionary histories. It has previously been shown that orthologous proteins may differ in domain architecture, creating challenges for orthology inference methods operating on full-length sequences. We have developed Domainoid, a new tool aiming to overcome these challenges faced by full-length orthology methods by inferring orthology on the domain level. It employs the InParanoid algorithm on single domains separately, to infer groups of orthologous domains.

Results

This domai

SUBMITTER: Persson E 

PROVIDER: S-EPMC6816169 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature