Pain REduction with bone metastases STereotactic radiotherapy (PREST): A phase III randomized multicentric trial.

ABSTRACT:

Background

Palliative antalgic treatments represent an issue for clinical management and a challenge for scientific research. Radiotherapy (RT) plays a central role. Techniques such as stereotactic body radiotherapy (SBRT) were largely investigated in several phase 2 studies with good symptom response, becoming widely adopted. However, evidence from randomized, direct comparison of RT and SBRT is still lacking.

Methods/design

The PREST trial was designed as an interventional study without medicinal treatment. It is a phase 3, open-label, multicentric trial randomized 1:1. Inclusion criteria include painful spinal bone metastases presenting with a pain level > 4 (or > 1 if being treated with an analgesic) on the Numeric Rating Scale (NRS); expected intermediate/high prognosis

SUBMITTER: Cellini F 

PROVIDER: S-EPMC6816218 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature