Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.

ABSTRACT: Cerium oxide nanoparticles (CeO₂NPs), used in some diesel fuel additives to improve fuel combustion efficiency and exhaust filter operation, have been detected in ambient air and concerns have been raised about their potential human health impact. The majority of CeO₂NP inhalation studies undertaken to date have used aerosol particles of larger sizes than the evidence suggests are emitted from vehicles using such fuel additives. Hence, the objective of this study was to investigate the effects of inhaled CeO₂NP aerosols of a more environmentally relevant size, utilizing a combination of methods, including untargeted multi-omics to enable the broadest possible survey of molecular responses and synchrotron X-ray spectroscopy to investigate cerium speciation.

SUBMITTER: Guo C 

PROVIDER: S-EPMC6816500 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature