Matrix feedback enables diverse higher-order patterning of the extracellular matrix.

ABSTRACT: The higher-order patterning of extra-cellular matrix in normal and pathological tissues has profound consequences on tissue function. Whilst studies have documented both how fibroblasts create and maintain individual matrix fibers and how cell migration is altered by the fibers they interact with, a model unifying these two aspects of tissue organization is lacking. Here we use computational modelling to understand the effect of this interconnectivity between fibroblasts and matrix at the mesoscale level. We created a unique adaptation to the Vicsek flocking model to include feedback from a second layer representing the matrix, and use experimentation to parameterize our model and validate model-driven hypotheses. Our two-layer model demonstrates that feedback between fibroblasts and matri

SUBMITTER: Wershof E 

PROVIDER: S-EPMC6816557 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature