Frailty, Implantable Cardioverter Defibrillators, and Mortality: a Systematic Review.

ABSTRACT:

Background

Evidence for the benefit of implantable cardioverter defibrillators (ICD) in preventing sudden cardiac death (SCD) in older adults is mixed; age alone may not predict benefit. Frailty may help identify patients in whom an ICD does not improve overall mortality risk.

Methods

Structured search of PubMed, Embase, Web of Science, and Cochrane Central Register of Controlled Trials on 1/31/2019, without language restriction, with terms for ICD, frailty, and mortality. Frailty was defined broadly using any validated single component (e.g., walking speed, weight loss) or multi-component tool (e.g., cumulative deficit index). Each study was assessed for quality and risk of bias.

Results

We identified and screened 2649 titles, reviewed 280 abstracts, and extracted 71

SUBMITTER: Chen MY 

PROVIDER: S-EPMC6816602 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature