Graphene Microelectrode Arrays for Electrical and Optical Measurements of Human Stem Cell-Derived Cardiomyocytes.

ABSTRACT:

Introduction

Cell-cell communication plays a pivotal role in biological systems' coordination and function. Electrical properties have been linked to specification and differentiation of stem cells into targeted progeny, such as neurons and cardiomyocytes. Currently, there is a critical need in developing new ways to complement fluorescent indicators, such as Ca²⁺-sensitive dyes, for direct electrophysiological measurements of cells and tissue. Here, we report a unique transparent and biocompatible graphene-based electrical platform that enables electrical and optical investigation of human embryonic stem cell-derived cardiomyocytes' (hESC-CMs) intracellular processes and intercellular communication.

Methods

Graphene, a honeycomb sp² hybridized two-dime

SUBMITTER: Rastogi SK 

PROVIDER: S-EPMC6816697 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature