Microenvironmental Modulation of Calcium Wave Propagation Velocity in Engineered Cardiac Tissues.

ABSTRACT:

Introduction

In the myocardium, rapid propagation of action potentials and subsequent calcium waves is critical for synchronizing the contraction of cardiac myocytes and maximizing cardiac output. In many pathological settings, diverse remodeling of the tissue microenvironment is correlated with arrhythmias and decreased cardiac output, but the precise impact of tissue remodeling on propagation is not completely understood. Our objective was to delineate how multiple features within the cardiac tissue microenvironment modulate propagation velocity.

Methods

To recapitulate diverse myocardial tissue microenvironments, we engineered substrates with tunable elasticity, patterning, composition, and topography using two formulations of polydimethylsiloxane (PDMS) micropatterned wi

SUBMITTER: Petersen AP 

PROVIDER: S-EPMC6816715 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature