High mobility group box 1 as a biomarker in critically ill patients.

ABSTRACT:

Background

Extracellular release of high mobility group box 1 (HMGB1) acts as a danger-associated molecular pattern, thereby "alarming" the immune system and promoting systemic inflammation. We investigated plasma HMGB1 concentrations as a potential diagnostic and prognostic biomarker in critical illness.

Methods

Our study included 218 critically ill patients (145 with sepsis, 73 without sepsis), of whom blood samples were obtained at the time-point of admission to the medical intensive care unit (ICU).

Results

High mobility group box 1 levels were significantly elevated in critically ill patients (n = 218) compared with healthy controls (n = 66). Elevated HMGB1 plasma levels were independent from the presence of sepsis. Moreover, HMGB1 was not associated with disease

SUBMITTER: Yagmur E 

PROVIDER: S-EPMC6816880 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature