Aberrant methylation of mutL homolog 1 is associated with increased risk of non-small cell lung cancer.

ABSTRACT:

Background

Non-small cell lung cancer (NSCLC) is a common malignant tumor. DNA hypermethylation in the promoter region has been served as a potential molecular marker for several tumors. The goal of the current study was to assess the diagnostic ability of mutL homolog 1 (MLH1) promoter methylation in NSCLC.

Methods

A total of 111 NSCLC patients' paired tissue samples were obtained to explore the association between MLH1 promoter methylation and NSCLC by methylation-specific polymerase chain reaction (MSP) method. Public databases including The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) were used to verify our findings.

Results

Our results showed a significantly higher MLH1 methylation frequency in tumor tissue samples than their paired adjacent tiss

SUBMITTER: Hu H 

PROVIDER: S-EPMC6816959 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature