Maternal IGF1 and IGF1R polymorphisms and the risk of spontaneous preterm birth.

ABSTRACT:

Background

The insulin-like growth factor (IGF) pathway was involved in the occurrence of spontaneous preterm birth (SPTB), but little is known regarding the relationship between genetic variations in IGF pathway and the risk of SPTB. We aimed to investigate the associations of IGF1 rs972936 and IGF1 receptor (IGF1R) rs2229765 polymorphisms with SPTB risk in a Chinese population.

Method

A total of 114 cases of SPTB and 250 controls of term delivery were included from Guangzhou Women and Children's Medical Center, China. The odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated using multivariate logistic regression.

Results

We found that the GA and GA/AA genotypes of IGF1 rs972936 were associated with an increased risk of SPTB, and the

SUBMITTER: He JR 

PROVIDER: S-EPMC6817009 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature