Measurement of HE4 and CA125 and establishment of reference intervals for the ROMA index in the sera of pregnant women.

ABSTRACT:

Introduction

Cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) are biomarkers for ovarian cancer. Their specificity and sensitivity are often limited during pregnancy as a result of great fluctuations. The risk of ovarian malignancy algorithm (ROMA) score, which combines CA125, HE4, and menopausal status, may improve diagnostic performance. There are no reports regarding the ROMA index in pregnant women. Therefore, the aim of our study was to establish appropriate reference intervals (RIs) for the ROMA index in pregnant Chinese women and compare them with those of CA125 and HE4 during pregnancy.

Methods

Serum concentrations of CA125 and HE4 were simultaneously measured in healthy pregnant women via electrochemiluminescence immunoassay (ECLIA). The ROMA index wa

SUBMITTER: Lu J 

PROVIDER: S-EPMC6817043 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature