HER2 Ile655Val polymorphism is negatively associated with breast cancer susceptibility.

ABSTRACT:

Background

The HER2 (human epidermal growth factor receptor-2) Ile655Val (rs1136201) genetic polymorphism can alter the receptor structure and its auto-activation, which can modify the signal transduction and, consequently, the cell cycle regulation. For this reason, this polymorphism has been extensively investigated as a candidate marker for breast cancer (BC). In this context, the aim of this study was to evaluate the possible influence of HER2 Ile655Val in BC susceptibility and prognostic factors in a Brazilian population.

Methods

Polymorphism genotype was assessed through RFLP-PCR in 107 BC patients with clinicopathological data available and in 150 women with no evidence of neoplasia and with no familial history of BC as control group. Association between this polymorp

SUBMITTER: de Almeida FC 

PROVIDER: S-EPMC6817048 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature