Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata.

ABSTRACT:

Background

Alopecia areata (AA), which appears as nonscarring hair shedding on any hair-bearing area, is a common organ-specific autoimmune condition. Cytokines have important roles in the development of AA. Interleukin (IL) 18 is a significant proinflammatory cytokine that was found higher in the patients with AA. We aimed to investigate whether the IL-18 (rs187238 and rs1946518) single nucleotide polymorphisms (SNPs) may be associated with AA and/or clinical outcome of patients with AA in Turkish population.

Methods

Genotyping of rs187238 and rs1946518 SNPs were detected using sequence-specific primer-polymerase chain reaction (SSP-PCR) method in 200 patients with AA and 200 control subjects.

Results

The genotype distribution of rs1946518 (-607C>A) SNP was found to

SUBMITTER: Celik SD 

PROVIDER: S-EPMC6817057 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature