Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population.

ABSTRACT:

Background

Many studies have revealed that transforming growth factor-beta (TGF-β) signals play important roles in maintaining normal status of articular cartilage in human osteoarthritis (OA). However, SMAD3 had inhibitory effect on TGF-β-induced chondrocyte maturation.

Method

To evaluate the association of SMAD3 genetic variants with the risk of knee OA, we conducted this hospital-based case-control study involving 350 knee patients with OA and 400 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single-nucleotide polymorphism (SNP) Scan^™ Kit.

Results

Our results indicate that the GG genotype of rs12901499 could decrease the risk of knee OA compared to AA genotype. However, stratified analyses by sex and age did

SUBMITTER: Zhang L 

PROVIDER: S-EPMC6817063 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature