Clinical relevance of peroxisome proliferator-activated receptor-γ gene polymorphisms with sepsis.

ABSTRACT:

Background

Peroxisome proliferator-activated receptor-γ (PPARγ) is a regulator of inflammation. This study aimed to explore associations between PPARγ gene single-nucleotide polymorphisms (SNPs) and susceptibility to and clinical outcome of sepsis in the North China Han population.

Methods

This study included 303 patients with sepsis and 303 controls. We conducted genetic typing for 13 common PPARγ gene SNPs (improved multiplex ligation detection reaction), linkage disequilibrium mapping, and haplotype inference. Associations between SNP genotypes/haplotypes and sepsis susceptibility and outcome (septic shock, organ dysfunction, or death) were assessed using unconditional logistic regression analysis.

Results

For rs2972164, patients with genotypes CT/CT+TT had higher

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6817069 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature