Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North-African Tunisian population.

ABSTRACT:

Background

Adiponectin, an adipocyte-derived protein, is known to play a key role in the processes leading to atherosclerosis and coronary artery disease (CAD) through its anti-atherogenic, anti-inflammatory, antioxidative, and anti-apoptotic properties. In the current study, we have studied the association of two single nucleotide polymorphisms (SNPs) +45 T>G (rs2241766) and +276 G>T (rs1501299) of the adiponectin gene with coronary artery disease (CAD) on an Arab/North-African population from Tunisia.

Methods

Subjects comprised 277 patients with angiographically demonstrated CAD and 269 age- and gender-matched control subjects. The adiponectin genotypes were performed by polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). The contributio

SUBMITTER: Ghazouani L 

PROVIDER: S-EPMC6817089 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature