Association study of polymorphisms in the ABO gene and their gene-gene interactions with ischemic stroke in Chinese population.

ABSTRACT:

Aims

To investigate the impact of 4 single nucleotide polymorphisms (SNPs) within ABO gene and their gene-gene interactions on ischemic stroke (IS) susceptibility in Chinese Han population.

Methods

A total of 1993 participants (1375 males, 618 females) were selected, including 991 IS patients and 1002 normal controls. The SNPstats (http://bioinfo.iconcologia.net/SNPstats) was used for Hardy-Weinberg equilibrium (HWE) test. Generalized multifactor dimensionality reduction (GMDR) was used to screen the best interaction combination among 4 SNPs within ABO gene. Logistic regression was performed to calculate the ORs (95%CI) for interaction between SNPs.

Results

Both rs579459 and rs505922 within ABO gene were associated with IS risk in additive and dominant models. IS risk

SUBMITTER: Li H 

PROVIDER: S-EPMC6817091 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature