Analysis of SLCO1B1 and APOE genetic polymorphisms in a large ethnic Hakka population in southern China.

ABSTRACT:

Objective

Statins are the most widely used lipid-lowering drugs, which have a significant effect on the inhibition of cardiovascular disease. The efficacy and side effects of statins are associated with the polymorphisms of SLCO1B1 and APOE genes. The purpose of this study was to analyze the SLCO1B1 and APOE gene polymorphisms in the Hakka population of southern China.

Methods

A total of 3249 subjects including 2019 males and 1230 females participated in this study. Polymerase chain reaction (PCR)-fluorescence probe technique for polymorphisms analysis and analyzed the genotypes frequencies of SLCO1B1 and APOE genes.

Results

The frequencies of SLCO1B1 521T>C between men and women were statistically significant (SLCO1B1 521TT, χ²  = 8.431, P = .004; SLCO1B1

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC6817202 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature