Noninvasive quantitative magnetization transfer MRI reveals tubulointerstitial fibrosis in murine kidney.

ABSTRACT: Excessive tissue scarring, or fibrosis, is a critical contributor to end stage renal disease, but current clinical tests are not sufficient for assessing renal fibrosis. Quantitative magnetization transfer (qMT) MRI provides indirect information about the macromolecular composition of tissues. We evaluated measurements of the pool size ratio (PSR, the ratio of immobilized macromolecular to free water protons) obtained by qMT as a biomarker of tubulointerstitial fibrosis in a well-established murine model with progressive renal disease. MR images were acquired from 16-week-old fibrotic hHB-EGF^Tg/Tg mice and normal wild-type (WT) mice (N = 12) at 7 T. QMT parameters were derived using a two-pool five-parameter fitting model. A normal range of PSR values in the cortex and outer str

SUBMITTER: Wang F 

PROVIDER: S-EPMC6817372 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature