Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy.

ABSTRACT:

Background

Allergen immunotherapy using synthetic peptide T-cell epitopes (Cat-PAD) from the major cat allergen Fel d 1 has been shown, in allergen exposure studies, to significantly reduce symptoms of allergic rhinoconjunctivitis in cat-allergic subjects. However, the immunological mechanisms underlying clinical benefit remain only partially understood. Since previous studies of whole allergen immunotherapy demonstrated a reduction in the frequency of allergen-specific (MHC II tetramer⁺ ) CD4⁺ T cells expressing the chemokine receptor CRTh2, we assessed the impact of Cat-PAD on the frequency and functional phenotype of Fel d 1-specific CD4⁺ T cells.

Methods

Using before and after treatment samples from subjects enrolled in a randomized, doub

SUBMITTER: Rudulier CD 

PROVIDER: S-EPMC6817377 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature