Estimation of cellular-interstitial water exchange in dynamic contrast enhanced MRI using two flip angles.

ABSTRACT:

Purpose

To investigate the feasibility of using multiple flip angles in dynamic contrast enhanced (DCE) MRI to reduce the uncertainty in estimation of intracellular water lifetime (τ_i ).

Methods

Numerical simulation studies were conducted to assess the uncertainty in estimation of τ_i using dynamic contrast enhanced MRI with one or two flip angles. In vivo experiments with a murine brain tumor model were conducted at 7T using two flip angles. The in vivo data were used to compare τ_i estimation using the single-flip-angle (SFA) protocol with that using the double-flip-angle (DFA) protocol. Data analysis was conducted using the two-compartment exchange model combined with the three-site-two-exchange model for water exchange.

Results

In th

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6817382 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature