Hyperpolarized ¹³ C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice.

ABSTRACT: Lipopolysaccharide (LPS) is a commonly used agent for induction of neuroinflammation in preclinical studies. Upon injection, LPS causes activation of microglia and astrocytes, whose metabolism alters to favor glycolysis. Assessing in vivo neuroinflammation and its modulation following therapy remains challenging, and new noninvasive methods allowing for longitudinal monitoring would be highly valuable. Hyperpolarized (HP) ¹³ C magnetic resonance spectroscopy (MRS) is a promising technique for assessing in vivo metabolism. In addition to applications in oncology, the most commonly used probe of [1-¹³ C] pyruvate has shown potential in assessing neuroinflammation-linked metabolism in mouse models of multiple sclerosis and traumatic brain injury. Here, we aimed to invest

SUBMITTER: Le Page LM 

PROVIDER: S-EPMC6817388 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature