Systemic Juvenile Idiopathic Arthritis-Associated Lung Disease: Characterization and Risk Factors.

ABSTRACT:

Objective

Systemic juvenile idiopathic arthritis (JIA) is associated with a recently recognized, albeit poorly defined and characterized, lung disease (LD). The objective of this study was to describe the clinical characteristics, risk factors, and histopathologic and immunologic features of this novel inflammatory LD associated with systemic JIA (designated SJIA-LD).

Methods

Clinical data collected since 2010 were abstracted from the medical records of patients with systemic JIA from the Cincinnati Children's Hospital Medical Center. Epidemiologic, cellular, biochemical, genomic, and transcriptional profiling analyses were performed.

Results

Eighteen patients with SJIA-LD were identified. Radiographic findings included diffuse ground-glass opacities, subpleural retic

SUBMITTER: Schulert GS 

PROVIDER: S-EPMC6817389 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature