Influences of Linker and Nucleoside for the Helical Self-Assembly of Perylene Along DNA Templates.

ABSTRACT: Six different conjugates of perylene with 2'-deoxyuridine and with 2-amino-2'-deoxyadenosine were synthesized and applied for DNA-templated assembly in aqueous buffer solutions. They differ by the linkers ethynylene, phenylene, and phenylene-ethynylene between nucleoside and chromophore. The nucleosides were investigated as monomers in CHCl3 and dimethyl sulfoxide by optical spectroscopy. The properties of the four phenylene-linked conjugates are similar to that of perylene as reference because these linkers separate both aromatic parts. The ethynylene linker electronically couples the chromophore with the respective nucleoside and thus red shifts the absorbance. The DNA-templated assembly properties were elucidated by mixing the templates in aqueous buffer with the perylene-nucleoside con

SUBMITTER: Fritz Y 

PROVIDER: S-EPMC6817502 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature