Cellular Blebs and Membrane Invaginations Are Coupled through Membrane Tension Buffering.

ABSTRACT: Bleb-type cellular protrusions play key roles in a range of biological processes. It was recently found that bleb growth is facilitated by a local supply of membrane from tubular invaginations, but the interplay between the expanding bleb and the membrane tubes remains poorly understood. On the one hand, the membrane area stored in tubes may serve as a reservoir for bleb expansion. On the other hand, the sequestering of excess membrane in stabilized invaginations may effectively increase the cell membrane tension, which suppresses spontaneous protrusions. Here, we investigate this duality through physical modeling and in vivo experiments. In agreement with observations, our model describes the transition into a tube-flattening mode of bleb expansion while also predicting that the blebbing

SUBMITTER: Lavi I 

PROVIDER: S-EPMC6817528 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature