Feasibility of Dose Escalating [¹⁸F]fluciclovine Positron Emission Tomography Positive Pelvic Lymph Nodes During Moderately Hypofractionated Radiation Therapy for High-Risk Prostate Cancer.

ABSTRACT:

Purpose

The aim of this study was to report the treatment planning feasibility of dose escalation to suspicious lymph nodes (LNs) for a series of men who underwent pretreatment [¹⁸F]fluciclovine positron emission tomography (PET)/magnetic resonance imaging (MRI).

Methods and materials

Cases of men with prostate cancer who enrolled in a clinical trial of pretreatment [¹⁸F]fluciclovine PET who had suspicious LNs were selected. Pelvic LNs <1 cm were defined as positive based on [¹⁸F]fluciclovine-PET if their maximum standardized uptake value (SUV_max) was ≥1.3-fold greater than the reference blood pool SUV_mean, and LNs ≥1 cm were defined as positive if the SUV was greater than the reference SUV bone marrow reference. For eac

SUBMITTER: McDonald AM 

PROVIDER: S-EPMC6817530 | biostudies-literature | 2019 Oct-Dec

REPOSITORIES: biostudies-literature