Immune Responses to Gametocyte Antigens in a Malaria Endemic Population-The African <i>falciparum</i> Context: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Malaria elimination remains a priority research agenda with the need for interventions that reduce and/or block malaria transmission from humans to mosquitoes. Transmission-blocking vaccines (TBVs) are in development, most of which target the transmission stage (i.e., gametocyte) antigens Pfs230 and Pfs48/45. For these interventions to be implemented, there is a need to understand the naturally acquired immunity to gametocytes. Several studies have measured the prevalence of immune responses to Pfs230 and Pfs48/45 in populations in malaria-endemic areas. Methods: We conducted a systematic review of studies carried out in African populations that measured the prevalence of immune responses to the gametocyte antigens Pfs230 and Pfs48/45. We assessed seroprevalence o

SUBMITTER: Muthui MK 

PROVIDER: S-EPMC6817591 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature