GABA_B Receptor Signaling in the Mesolimbic System Suppresses Binge-like Consumption of a High-Fat Diet.

ABSTRACT: Binge eating could contribute to the development of obesity, and previous studies suggest that gamma-aminobutyric acid (GABA) type B receptor (GABA_BR) signaling is involved in the regulation of binge eating. Here, we show that time-restricted access to a high-fat diet (HFD) induces binge-like eating behavior in wild-type mice. HFD consumption during restricted time was significantly increased in corticostriatal neuron-specific GABA_BR-deficient mice compared with wild-type mice. Furthermore, the GABA_BR agonist baclofen suppressed HFD intake during restricted time in wild-type mice but not in corticostriatal or dopaminergic neuron-specific GABA_BR-deficient mice. In contrast, there were no significant differences in food consumption among genotypes

SUBMITTER: Tsunekawa T 

PROVIDER: S-EPMC6817655 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature