Genome-wide association study identifies seven novel loci associating with circulating cytokines and cell adhesion molecules in Finns.

ABSTRACT:

Background

Inflammatory processes contribute to the pathophysiology of multiple chronic conditions. Genetic factors play a crucial role in modulating the inflammatory load, but the exact mechanisms are incompletely understood.

Objective

To assess genetic determinants of 16 circulating cytokines and cell adhesion molecules (inflammatory phenotypes) in Finns.

Methods

Genome-wide associations of the inflammatory phenotypes were studied in Northern Finland Birth Cohort 1966 (N=5284). A subsequent meta-analysis was completed for 10 phenotypes available in a previous genome-wide association study, adding up to 13 577 individuals in the study. Complementary association tests were performed to study the effect of the ABO blood types on soluble adhesion molecule levels.

Res

SUBMITTER: Sliz E 

PROVIDER: S-EPMC6817708 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature