The Ancestral Environment Shapes Antiviral CD8⁺ T cell Responses across Generations.

ABSTRACT: Recent studies have linked health fates of children to environmental exposures of their great grandparents. However, few studies have considered whether ancestral exposures influence immune function across generations. Here, we report transgenerational inheritance of altered T cell responses resulting from maternal (F0) exposure to the aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Since F0 exposure to TCDD has been linked to transgenerational transmission of reproductive problems, we asked whether maternal TCDD exposure also caused transgenerational changes in immune function. F0 exposure caused transgenerational effects on the CD8⁺ T cell response to influenza virus infection in females but not in males. Outcrosses showed changes were passed throu

SUBMITTER: Post CM 

PROVIDER: S-EPMC6817732 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature