Low systemic arterial compliance is associated with increased cardiovascular morbidity and mortality in aortic valve stenosis.

ABSTRACT:

Objective

Lower systemic arterial compliance (SAC) is associated with increased cardiovascular morbidity and mortality in hypertension, but this has not been assessed in a prospective study in aortic valve stenosis (AS).

Methods

Data from 1641 patients (38% women) with initially asymptomatic mild-moderate AS enrolled in the Simvastatin and Ezetimibe in Aortic Stenosis study was used. Median follow-up was 4.3 years. SAC was assessed from Doppler stroke volume index to central pulse pressure ratio and considered low if ≤0.64 mL/m², corresponding to the lower tertile in the population. The association of SAC with outcome was assessed in Cox regression analysis and reported as HR and 95% CI.

Results

Low SAC at baseline was characterised by older age, female sex, hypertens

SUBMITTER: Bahlmann E 

PROVIDER: S-EPMC6817765 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature