Synapsins are expressed at neuronal and non-neuronal locations in Octopus vulgaris.

ABSTRACT: Synapsins are a family of phosphoproteins fundamental to the regulation of neurotransmitter release. They are typically neuron-specific, although recent evidence pointed to their expression in non-neuronal cells where they play a role in exocytosis and vesicle trafficking. In this work, we characterized synapsin transcripts in the invertebrate mollusk Octopus vulgaris and present evidence of their expression not only in the brain but also in male and female reproductive organs. We identified three synapsin isoforms phylogenetically correlated to that of other invertebrates and with a modular structure characteristic of mammalian synapsins with a central, highly conserved C domain, important for the protein functions, and less conserved A, B and E domains. Our molecular modeling analysis fu

SUBMITTER: Maiole F 

PROVIDER: S-EPMC6817820 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature