Clonal expansion of a virulent Streptococcus suis serotype 9 lineage distinguishable from carriage subpopulations.

ABSTRACT: Streptococcus suis is a porcine pathogen, causing severe invasive infections. S. suis serotype 9 is increasingly causing disease in Dutch and Chinese pig herds, but it is unknown whether all serotype 9 isolates are equally virulent and markers that can identify virulent strains are not available. Therefore, discrimination between virulent isolates and carriage isolates typically not associated with disease, is currently not possible. We collected tonsillar S. suis isolates from 6 herds not previously diagnosed with S. suis infections, and clinical S. suis isolates of previously diseased pigs. We confirmed the virulence of a virulent type strain and one representative clinical isolate, and the lack of virulence of two carriage isolates, in a pig infection model. Phylogenetic analysis of who

SUBMITTER: Willemse N 

PROVIDER: S-EPMC6817849 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature