Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) is characterized by a progressive loss of neurons and cognitive functions. Therefore, early diagnosis of AD is critical. The development of practical and non-invasive diagnostic tests for AD remains, however, an unmet need. In the present proof-of-concept study we investigated tear fluid as a novel source of disease-specific protein and microRNA-based biomarkers for AD development using samples from patients with mild cognitive impairment (MCI) and AD. Tear protein content was evaluated via liquid chromatography-mass spectrometry and microRNA content was profiled using a genome-wide high-throughput PCR-based platform. These complementary approaches identified enrichment of specific proteins and microRNAs in tear fluid of AD patients. In particular, we identified el

SUBMITTER: Kenny A 

PROVIDER: S-EPMC6817868 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature