Association study of genetic variants of the ANGPTL3 gene and susceptibility to ischemic stroke.

ABSTRACT:

Background

Stroke ranks as the third-leading cause of years of life lost worldwide. ANGPTL3 plays important roles in lipid metabolism, atherosclerosis, and occurrence of stroke. The purpose of this study was to evaluate associations of genetic variants in the ANGPTL3 gene with ischemic stroke (IS) risk.

Methods

A case-control study was conducted to evaluate the associations of tag single-nucleotide polymorphisms (SNPs) of the ANGPTL3 gene and risk of IS, as well as serum lipid levels. Dual-luciferase reporter assays in the HEK293T cell line was conducted to evaluate the promoter activity of ANGPTL3 rs6690733.

Results

We found rs6690733 (C vs A: OR 1.34, 95% CI 1.13-1.59; P=0.001) and rs12563308 (C vs T: OR 0.77, 95% CI 0.64-0.93, P=0

SUBMITTER: Gong Q 

PROVIDER: S-EPMC6817949 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature