Multiscale Computational Modeling of Tubulin-Tubulin Lateral Interaction.

ABSTRACT: Microtubules are multistranded polymers in eukaryotic cells that support key cellular functions such as chromosome segregation, motor-based cargo transport, and maintenance of cell polarity. Microtubules self-assemble via "dynamic instability," in which the dynamic plus ends switch stochastically between alternating phases of polymerization and depolymerization. A key question in the field is what are the atomistic origins of this switching, i.e., what is different between the GTP- and GDP-tubulin states that enables microtubule growth and shortening, respectively? More generally, a major challenge in biology is how to connect theoretical frameworks across length- and timescales, from atoms to cellular behavior. In this study, we describe a multiscale model by linking atomistic molecular d

SUBMITTER: Hemmat M 

PROVIDER: S-EPMC6818183 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature