Association study of the functional Catechol-O-Methyltranferase (COMT) Val¹⁵⁸Met polymorphism on executive cognitive function in a Thai sample.

ABSTRACT: Catechol-O-Methyltranferase (COMT) plays a crucial role in the removal of cortical dopamine and is strongly implicated in human executive function. Numerous studies have reported associations of the COMT Val158Met (rs4680) polymorphism with executive function in healthy subjects. However, little work has investigated this in the Thai population and the relationship of age and education with this association remains unclear. Therefore, this study was designed to investigate the association of this polymorphism of the COMT gene with executive cognitive brain function in healthy subjects and the relationship with age and education. The Wisconsin Card Sorting Test (WCST) was performed to assess executive function in 254 healthy Thai subjects (aged 20-72 years). The results showed a significant

SUBMITTER: Khanthiyong B 

PROVIDER: S-EPMC6818203 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature