Longitudinal analysis of bronchodilator response in asthmatics and effect modification of age-related trends by genotype.

ABSTRACT:

Background and objectives

Genome Wide Association Studies (GWAS) have identified genetic polymorphisms associated with bronchodilator response (BDR), but it is unknown how these associations change across life stages. We examined the impact of genetic variants on BDR from childhood to adulthood in asthmatics to uncover potential effect modification by age.

Methods

We searched the National Human Genome Research Institute (NHGRI) catalog of published GWAS to obtain a list of genetic associations with BDR, and tested them for effect modification by age in 604 subjects from the Childhood Asthma Management Program (CAMP), a clinical trial with longitudinal measures of BDR (age range 5-30 years). We performed longitudinal analyses using linear mixed models and visualized longitudi

SUBMITTER: Sordillo JE 

PROVIDER: S-EPMC6818258 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature